NEF capture and open in either Adobe Camera RAW or Capture One Pro – depends on the image (if the image is ultra high-contrast, I prefer Capture One over Adobe Camera Raw. Abobe has problems with tonal gradations and posterization often occurs with high, high contrast images)
I make as many adjustments as possible in the RAW converter. I shoot in AdobeRGB, work in AdobeRGB. save in AdobeRGB. I set my image size to 200 percent and SAVE to dng. I prefer dngs to psds or keeping the original nef because it saves all of your RAW work without the sidecar file. dngs are slowly becoming universal in their acceptance.
Then I open straight to Photoshop. Make final touchups and save an unsharpened TIFF file to my harddrive, alongside the matching dng. The TIFF is a flattened 16-bit, AdobeRGB file, approximately 143 MB.
If I want to make a print, I open the TIFF in Photoshop then duplicate. Close the original and work with the copy only. If I want an 8×12 print, I resize to 8 x 12, 300 ppi. Convert from 16-bit to 8-bit. Then I sharpen the image for final output. I use Pixel Genius output sharpener. It automatically adjusts for ppi and image size.